Alpha-1 Translational Research Laboratory

The Alpha-1 Translational Research Laboratory is devoted to characterizing the molecular mechanisms responsible for the development of liver and lung disease in AAT Deficient individuals and to the development of new treatments.

Funded by a Grant from the Alpha-1 Foundation:

• Mapping the Role of Unfolded Protein Response Genes in Hepatocytes Expressing Z Alpha-1-Antitrypsin
• The role of apoptosis in lung inflammation and injury in alpha-1-antitrypsin deficiency
• Identification of Rare Alpha-1-Antitrypsin Gene Mutations by High Resolution DNA Melt Analysis