Jungnam Lee

Jungnam Lee,

About Jungnam Lee

I am very interested in discovering mechanisms by which AATD leads to lung diseases and identifying potential early indicators of the disease or therapeutic target to reduce the burden of AATD-related diseases. I have been working in the field of molecular and cell biology for more than a decade, publishing 29 research articles. During my doctoral study, I worked on genomics, analyzing DNA sequencing data from various species. While I worked as a postdoctoral fellow, I cultured various types of human cells including primary gingival epithelial cells and discovered a possible cellular signaling responsible for pathogenesis of oral cancer. In my current lab, I have been working on monocyte-derived macrophages, examining the effect of AATD on macrophage efferocytosis of apoptotic cells and phagocytosis of bacteria.

Accomplishments

Korean honor scholarship
2007 · Government of the Republic of Korea
Vice Chancellor’s Graduate Enhancement
2005-2008 · Louisiana State University
Research Enhancement
2001 · Dankook University
Scholarship for good achievements
1997-1999 · Dankook University

Research Profile

I am very interested in discovering mechanisms by which AATD leads to lung diseases and identifying potential early indicators of the disease or therapeutic target to reduce the burden of AATD-related diseases.

Publications

2020
Alpha 1 Antitrypsin-Deficient Macrophages Have Impaired Efferocytosis of Apoptotic Neutrophils.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.574410. [PMID] 33329539.
2019
Activation of vitamin D in the gingival epithelium and its role in gingival inflammation and alveolar bone loss
.
2018
A novel kinase function of a nucleoside-diphosphate-kinase homologue in Porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat-shock protein
.
2018
A novel kinase function of a nucleoside-diphosphate-kinase homologue in Porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat-shock protein 27.
Cellular microbiology. 20(5) [DOI] 10.1111/cmi.12825. [PMID] 29359393.
2018
Bronchoalveolar lavage (BAL) cells in idiopathic pulmonary fibrosis express a complex pro-inflammatory, pro-repair, angiogenic activation pattern, likely associated with macrophage iron accumulation.
PloS one. 13(4) [DOI] 10.1371/journal.pone.0194803. [PMID] 29649237.
2017
Human Primary Epithelial Cells Acquire an Epithelial-Mesenchymal-Transition Phenotype during Long-Term Infection by the Oral Opportunistic Pathogen, Porphyromonas gingivalis.
Frontiers in cellular and infection microbiology. 7 [DOI] 10.3389/fcimb.2017.00493. [PMID] 29250491.
2017
Opportunistic Pathogen Porphyromonas gingivalis Modulates Danger Signal ATP-Mediated Antibacterial NOX2 Pathways in Primary Epithelial Cells.
Frontiers in cellular and infection microbiology. 7 [DOI] 10.3389/fcimb.2017.00291. [PMID] 28725637.
2016
Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome-dependent secretion of IL-1β and the danger signals ASC and HMGB1.
Cellular microbiology. 18(7):970-81 [DOI] 10.1111/cmi.12560. [PMID] 26687842.
2016
Nucleoside-Diphosphate-Kinase of P. gingivalis is Secreted from Epithelial Cells In the Absence of a Leader Sequence Through a Pannexin-1 Interactome.
Scientific reports. 6 [DOI] 10.1038/srep37643. [PMID] 27883084.
2016
Structural Variation of Alu Element and Human Disease.
Genomics & informatics. 14(3):70-77 [PMID] 27729835.
2015
Porphyromonas gingivalis attenuates ATP-mediated inflammasome activation and HMGB1 release through expression of a nucleoside-diphosphate kinase.
Microbes and infection. 17(5):369-77 [DOI] 10.1016/j.micinf.2015.03.010. [PMID] 25828169.
2014
Chimpanzee-specific endogenous retrovirus generates genomic variations in the chimpanzee genome.
PloS one. 9(7) [DOI] 10.1371/journal.pone.0101195. [PMID] 24987855.

Education

Ph.D.
2008 · Louisiana State University

Contact Details

Phones:
Business:
(352) 273-8737
Emails:
Addresses:
Business Mailing:
PO Box 100225
GAINESVILLE FL 32610
Business Street:
PO BOX 100225
Division of Pulmonary, Critical Care, & Sleep Medicine
GAINESVILLE FL 32611