Yuanqing Lu,
Faculty, Asst Scientist.
Department:
MD-NEUROLOGICAL SURGERY
Business Phone:
(352) 273-9000
Business Email:
yuanqing.lu@medicine.ufl.edu
Publications
2023
Alpha-defensins inhibit ERK/STAT3 signaling during monocyte-macrophage differentiation and impede macrophage function.
Respiratory research.
24(1)
[DOI] 10.1186/s12931-023-02605-0.
[PMID] 38082274.
2022
Alu RNA induces NLRP3 expression through TLR7 activation in α-1-antitrypsin-deficient macrophages.
JCI insight.
7(12)
[DOI] 10.1172/jci.insight.158791.
[PMID] 35730566.
2022
Characterization of hepatic inflammatory changes in a C57BL/6J mouse model of alpha1-antitrypsin deficiency.
American journal of physiology. Gastrointestinal and liver physiology.
323(6):G594-G608
[DOI] 10.1152/ajpgi.00207.2022.
[PMID] 36256438.
2022
Reply.
Hepatology communications.
6(12)
[DOI] 10.1002/hep4.2084.
[PMID] 36017787.
2022
The unfolded protein response to PI*Z alpha-1 antitrypsin in human hepatocellular and murine models.
Hepatology communications.
6(9):2354-2367
[DOI] 10.1002/hep4.1997.
[PMID] 35621045.
2021
Emergency myelopoiesis contributes to immune cell exhaustion and pulmonary vascular remodelling.
British journal of pharmacology.
178(1):187-202
[DOI] 10.1111/bph.14945.
[PMID] 31793661.
2021
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
International journal of molecular sciences.
22(24)
[DOI] 10.3390/ijms222413255.
[PMID] 34948056.
2020
Alpha 1 Antitrypsin-Deficient Macrophages Have Impaired Efferocytosis of Apoptotic Neutrophils.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.574410.
[PMID] 33329539.
2019
A checkpoint on innate myeloid cells in pulmonary arterial hypertension
Pulmonary Circulation.
9(1)
2019
Alpha-1-Antitrypsin Ameliorates Pristane Induced Diffuse Alveolar Hemorrhage in Mice.
Journal of clinical medicine.
8(9)
[DOI] 10.3390/jcm8091341.
[PMID] 31470606.
2019
Chemokine signaling axis between endothelial and myeloid cells regulates development of pulmonary hypertension associated with pulmonary fibrosis and hypoxia.
American journal of physiology. Lung cellular and molecular physiology.
317(4):L434-L444
[DOI] 10.1152/ajplung.00156.2019.
[PMID] 31364370.
2019
Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes.
Journal of clinical medicine.
8(9)
[DOI] 10.3390/jcm8091321.
[PMID] 31466263.
2018
Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice.
Molecular therapy. Methods & clinical development.
11:131-142
[DOI] 10.1016/j.omtm.2018.10.007.
[PMID] 30547047.
2018
Anti-inflammaging effects of human alpha-1 antitrypsin.
Aging cell.
17(1)
[DOI] 10.1111/acel.12694.
[PMID] 29045001.
2018
Gene Delivery of Alpha-1-Antitrypsin Using Recombinant Adeno-Associated Virus (rAAV).
Methods in molecular biology (Clifton, N.J.).
1826:183-196
[DOI] 10.1007/978-1-4939-8645-3_12.
[PMID] 30194601.
2018
In Vivo Analysis of Alpha-1-Antitrypsin Functions in Autoimmune Disease Models.
Methods in molecular biology (Clifton, N.J.).
1826:143-155
[DOI] 10.1007/978-1-4939-8645-3_10.
[PMID] 30194599.
2018
Vascular Endothelial Cell-Specific Connective Tissue Growth Factor (CTGF) Is Necessary for Development of Chronic Hypoxia-Induced Pulmonary Hypertension.
Frontiers in physiology.
9
[DOI] 10.3389/fphys.2018.00138.
[PMID] 29535639.
2017
Erdj3 Has an Essential Role for Z Variant Alpha-1-Antitrypsin Degradation.
Journal of cellular biochemistry.
118(10):3090-3101
[DOI] 10.1002/jcb.26069.
[PMID] 28419579.
2017
Transplantation of Adipose Tissue-Derived Mesenchymal Stem Cell (ATMSC) Expressing Alpha-1 Antitrypsin Reduces Bone Loss in Ovariectomized Osteoporosis Mice.
Human gene therapy.
28(2):179-189
[DOI] 10.1089/hum.2016.069.
[PMID] 27802778.
2016
Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus.
PloS one.
11(5)
[DOI] 10.1371/journal.pone.0156583.
[PMID] 27232337.
2016
Alpha-1 Antitrypsin Gene Therapy Ameliorates Bone Loss in Ovariectomy-Induced Osteoporosis Mouse Model.
Human gene therapy.
27(9):679-86
[DOI] 10.1089/hum.2016.029.
[PMID] 27158796.
2015
In Situ Transplantation of Alginate Bioencapsulated Adipose Tissues Derived Stem Cells (ADSCs) via Hepatic Injection in a Mouse Model.
PloS one.
10(9)
[DOI] 10.1371/journal.pone.0138184.
[PMID] 26372641.
2014
Alpha 1-antitrypsin therapy mitigated ischemic stroke damage in rats.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
23(5):e355-63
[DOI] 10.1016/j.jstrokecerebrovasdis.2013.12.029.
[PMID] 24582784.
2014
Reprogramming adipose tissue-derived mesenchymal stem cells into pluripotent stem cells by a mutant adeno-associated viral vector.
Human gene therapy methods.
25(1):72-82
[DOI] 10.1089/hgtb.2013.011.
[PMID] 24191859.
2011
Adipose tissue-derived mesenchymal stem cell-based liver gene delivery.
Journal of hepatology.
54(5):930-8
[DOI] 10.1016/j.jhep.2010.07.051.
[PMID] 21168381.
2010
Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis.
The journal of gene medicine.
12(1):35-44
[DOI] 10.1002/jgm.1409.
[PMID] 19866480.
2010
Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin.
Molecular therapy : the journal of the American Society of Gene Therapy.
18(8):1553-8
[DOI] 10.1038/mt.2010.116.
[PMID] 20551917.
2010
Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease.
Diabetologia.
53(10):2198-204
[DOI] 10.1007/s00125-010-1829-2.
[PMID] 20593162.
2010
Transduction and Transplantation of Bone Marrow Cells for Liver Gene Delivery of α1-Antitrypsin
.
18(8)
2009
Distinct immune responses to transgene products from rAAV1 and rAAV8 vectors.
Proceedings of the National Academy of Sciences of the United States of America.
106(40):17158-62
[DOI] 10.1073/pnas.0909520106.
[PMID] 19805176.
2008
Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice.
Clinical and experimental immunology.
154(1):15-21
[DOI] 10.1111/j.1365-2249.2008.03721.x.
[PMID] 18759852.
2007
Alpha1-antitrypsin protects beta-cells from apoptosis.
Diabetes.
56(5):1316-23
[PMID] 17360983.
2006
Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice.
Human gene therapy.
17(6):625-34
[PMID] 16776571.
2006
Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector.
The journal of gene medicine.
8(6):730-5
[PMID] 16518879.
2004
DNA-dependent PK inhibits adeno-associated virus DNA integration.
Proceedings of the National Academy of Sciences of the United States of America.
101(7):2112-6
[PMID] 14766968.
2004
Ex vivo transduced liver progenitor cells as a platform for gene therapy in mice.
Hepatology (Baltimore, Md.).
40(4):918-24
[PMID] 15382177.
Contact Details
Phones:
- Business:
- (352) 273-9000
Emails:
- Business:
- yuanqing.lu@medicine.ufl.edu
Addresses:
- Business Mailing:
-
PO BOX 100265
GAINESVILLE FL 32610 - Business Street:
-
1333 Center Drive
GAINESVILLE FL 32610