Yuanqing Lu

Yuanqing Lu,

Faculty, Asst Scientist.

Department: MD-PULMONARY MEDICINE
Business Phone: (352) 294-5199

Publications

2022
Alu RNA induces NLRP3 expression through TLR7 activation in α-1-antitrypsin-deficient macrophages.
JCI insight. 7(12) [DOI] 10.1172/jci.insight.158791. [PMID] 35730566.
2022
The unfolded protein response to PI*Z alpha-1 antitrypsin in human hepatocellular and murine models.
Hepatology communications. 6(9):2354-2367 [DOI] 10.1002/hep4.1997. [PMID] 35621045.
2021
Emergency myelopoiesis contributes to immune cell exhaustion and pulmonary vascular remodelling.
British journal of pharmacology. 178(1):187-202 [DOI] 10.1111/bph.14945. [PMID] 31793661.
2021
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
International journal of molecular sciences. 22(24) [DOI] 10.3390/ijms222413255. [PMID] 34948056.
2020
Alpha 1 Antitrypsin-Deficient Macrophages Have Impaired Efferocytosis of Apoptotic Neutrophils.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.574410. [PMID] 33329539.
2019
A checkpoint on innate myeloid cells in pulmonary arterial hypertension
Pulmonary Circulation. 9(1)
2019
Alpha-1-Antitrypsin Ameliorates Pristane Induced Diffuse Alveolar Hemorrhage in Mice.
Journal of clinical medicine. 8(9) [DOI] 10.3390/jcm8091341. [PMID] 31470606.
2019
Chemokine signaling axis between endothelial and myeloid cells regulates development of pulmonary hypertension associated with pulmonary fibrosis and hypoxia.
American journal of physiology. Lung cellular and molecular physiology. 317(4):L434-L444 [DOI] 10.1152/ajplung.00156.2019. [PMID] 31364370.
2019
Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes.
Journal of clinical medicine. 8(9) [DOI] 10.3390/jcm8091321. [PMID] 31466263.
2018
Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice.
Molecular therapy. Methods & clinical development. 11:131-142 [DOI] 10.1016/j.omtm.2018.10.007. [PMID] 30547047.
2018
Anti-inflammaging effects of human alpha-1 antitrypsin.
Aging cell. 17(1) [DOI] 10.1111/acel.12694. [PMID] 29045001.
2018
Gene Delivery of Alpha-1-Antitrypsin Using Recombinant Adeno-Associated Virus (rAAV).
Methods in molecular biology (Clifton, N.J.). 1826:183-196 [DOI] 10.1007/978-1-4939-8645-3_12. [PMID] 30194601.
2018
In Vivo Analysis of Alpha-1-Antitrypsin Functions in Autoimmune Disease Models.
Methods in molecular biology (Clifton, N.J.). 1826:143-155 [DOI] 10.1007/978-1-4939-8645-3_10. [PMID] 30194599.
2018
Vascular Endothelial Cell-Specific Connective Tissue Growth Factor (CTGF) Is Necessary for Development of Chronic Hypoxia-Induced Pulmonary Hypertension.
Frontiers in physiology. 9 [DOI] 10.3389/fphys.2018.00138. [PMID] 29535639.
2017
Erdj3 Has an Essential Role for Z Variant Alpha-1-Antitrypsin Degradation.
Journal of cellular biochemistry. 118(10):3090-3101 [DOI] 10.1002/jcb.26069. [PMID] 28419579.
2017
Transplantation of Adipose Tissue-Derived Mesenchymal Stem Cell (ATMSC) Expressing Alpha-1 Antitrypsin Reduces Bone Loss in Ovariectomized Osteoporosis Mice.
Human gene therapy. 28(2):179-189 [DOI] 10.1089/hum.2016.069. [PMID] 27802778.
2016
Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus.
PloS one. 11(5) [DOI] 10.1371/journal.pone.0156583. [PMID] 27232337.
2016
Alpha-1 Antitrypsin Gene Therapy Ameliorates Bone Loss in Ovariectomy-Induced Osteoporosis Mouse Model.
Human gene therapy. 27(9):679-86 [DOI] 10.1089/hum.2016.029. [PMID] 27158796.
2015
In Situ Transplantation of Alginate Bioencapsulated Adipose Tissues Derived Stem Cells (ADSCs) via Hepatic Injection in a Mouse Model.
PloS one. 10(9) [DOI] 10.1371/journal.pone.0138184. [PMID] 26372641.
2014
Alpha 1-antitrypsin therapy mitigated ischemic stroke damage in rats.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 23(5):e355-63 [DOI] 10.1016/j.jstrokecerebrovasdis.2013.12.029. [PMID] 24582784.
2014
Reprogramming adipose tissue-derived mesenchymal stem cells into pluripotent stem cells by a mutant adeno-associated viral vector.
Human gene therapy methods. 25(1):72-82 [DOI] 10.1089/hgtb.2013.011. [PMID] 24191859.
2011
Adipose tissue-derived mesenchymal stem cell-based liver gene delivery.
Journal of hepatology. 54(5):930-8 [DOI] 10.1016/j.jhep.2010.07.051. [PMID] 21168381.
2010
Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis.
The journal of gene medicine. 12(1):35-44 [DOI] 10.1002/jgm.1409. [PMID] 19866480.
2010
Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin.
Molecular therapy : the journal of the American Society of Gene Therapy. 18(8):1553-8 [DOI] 10.1038/mt.2010.116. [PMID] 20551917.
2010
Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease.
Diabetologia. 53(10):2198-204 [DOI] 10.1007/s00125-010-1829-2. [PMID] 20593162.
2010
Transduction and Transplantation of Bone Marrow Cells for Liver Gene Delivery of α1-Antitrypsin
. 18(8)
2009
Distinct immune responses to transgene products from rAAV1 and rAAV8 vectors.
Proceedings of the National Academy of Sciences of the United States of America. 106(40):17158-62 [DOI] 10.1073/pnas.0909520106. [PMID] 19805176.
2008
Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice.
Clinical and experimental immunology. 154(1):15-21 [DOI] 10.1111/j.1365-2249.2008.03721.x. [PMID] 18759852.
2007
Alpha1-antitrypsin protects beta-cells from apoptosis.
Diabetes. 56(5):1316-23 [PMID] 17360983.
2006
Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice.
Human gene therapy. 17(6):625-34 [PMID] 16776571.
2006
Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector.
The journal of gene medicine. 8(6):730-5 [PMID] 16518879.
2004
DNA-dependent PK inhibits adeno-associated virus DNA integration.
Proceedings of the National Academy of Sciences of the United States of America. 101(7):2112-6 [PMID] 14766968.
2004
Ex vivo transduced liver progenitor cells as a platform for gene therapy in mice.
Hepatology (Baltimore, Md.). 40(4):918-24 [PMID] 15382177.

Contact Details

Phones:
Business:
(352) 294-5199
Emails:
Addresses:
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PO Box 100225
GAINESVILLE FL 32610
Business Street:
P4-12 BLDG 0445
GAINESVILLE FL 32611