Nazli Khodayari

Nazli Khodayari,

Assistant Professor

Department: MD-PULMONARY MEDICINE
Business Phone: (352) 294-5198
Business Email: nazlikhodayari@ufl.edu

Teaching Profile

Courses Taught
2021-2023
GMS6001 Fundamentals of Biomedical Sciences I

Research Profile

The long-term goal of Dr. Khodayari is to obtain knowledge and develop treatments for human diseases including, but not limited to, Liver disease and inflammatory diseases. Extracellular vesicles are critical in organ and cellular cross-talk. Dr. Khodayari’s interest is on the rule of extracellular vesicles and organ cross-talk in inflammatory diseases.

Open Researcher and Contributor ID (ORCID)

0000-0002-4659-1622

Publications

2024
Sirtuin3 promotes the degradation of hepatic Z alpha-1 antitrypsin through lipophagy.
Hepatology communications. 8(2) [DOI] 10.1097/HC9.0000000000000370. [PMID] 38285890.
2023
Augmentation Therapy Modulates Systemic Inflammation in Individuals with Alpha-1 Antitrypsin Deficiency and Chronic Obstructive Pulmonary Disease.
Chronic obstructive pulmonary diseases (Miami, Fla.). 10(3):308-316 [DOI] 10.15326/jcopdf.2023.0407. [PMID] 37363834.
2023
Correction to: Cigarette smoke exposed airway epithelial cells-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency.
Respiratory research. 24(1) [DOI] 10.1186/s12931-023-02571-7. [PMID] 37925417.
2023
Lung Inflammation in alpha-1-antitrypsin deficient individuals with normal lung function.
Respiratory research. 24(1) [DOI] 10.1186/s12931-023-02343-3. [PMID] 36732772.
2023
Using ChatGPT to predict the future of personalized medicine.
The pharmacogenomics journal. 23(6):178-184 [DOI] 10.1038/s41397-023-00316-9. [PMID] 37726551.
2022
BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1.
iScience. 25(12) [DOI] 10.1016/j.isci.2022.105626. [PMID] 36471805.
2022
Characterization of hepatic inflammatory changes in a C57BL/6J mouse model of alpha1-antitrypsin deficiency
American Journal of Physiology-Gastrointestinal and Liver Physiology. 323(6):G594-G608 [DOI] 10.1152/ajpgi.00207.2022.
2022
Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency.
Respiratory research. 23(1) [DOI] 10.1186/s12931-022-02161-z. [PMID] 36068572.
2022
Correlation of alpha-1 antitrypsin levels and exosome associated neutrophil elastase endothelial injury in subjects with SARS-CoV2 infection
PLOS ONE. 17(9) [DOI] 10.1371/journal.pone.0274427. [PMID] 36084115.
2022
Reply
Hepatology Communications. 6(12):3599-3599 [DOI] 10.1002/hep4.2084. [PMID] 36017787.
2022
The unfolded protein response to PI*Z alpha‐1 antitrypsin in human hepatocellular and murine models
Hepatology Communications. 6(9):2354-2367 [DOI] 10.1002/hep4.1997. [PMID] 35621045.
2021
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
International journal of molecular sciences. 22(24) [DOI] 10.3390/ijms222413255. [PMID] 34948056.
2020
Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo
Cell Communication and Signaling. 18(1) [DOI] 10.1186/s12964-020-00648-0. [PMID] 32887613.
2020
Gut microbiota: a perspective of precision medicine in endocrine disorders.
Journal of diabetes and metabolic disorders. 19(2):1827-1834 [DOI] 10.1007/s40200-020-00593-2. [PMID] 33520863.
2020
Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-72667-3. [PMID] 32981934.
2019
Modulation of calreticulin expression reveals a novel exosome-mediated mechanism of Z variant α1-antitrypsin disposal
Journal of Biological Chemistry. 294(16):6240-6252 [DOI] 10.1074/jbc.ra118.006142.
2019
Modulation of calreticulin expression reveals a novel mechanism of Z variant alpha-1 Antitrypsin disposal.
Molecular Biology of the Cell. 28
2017
Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity.
American journal of respiratory cell and molecular biology. 57(2):238-247 [DOI] 10.1165/rcmb.2016-0366OC. [PMID] 28362108.
2017
Erdj3 Has an Essential Role for Z Variant Alpha‐1‐Antitrypsin Degradation
Journal of Cellular Biochemistry. 118(10):3090-3101 [DOI] 10.1002/jcb.26069. [PMID] 28419579.
2017
SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78.
PloS one. 12(3) [DOI] 10.1371/journal.pone.0172983. [PMID] 28301499.
2016
MicroRNA-302b targets Mcl-1 and inhibits cell proliferation and induces apoptosis in malignant pleural mesothelioma cells.
American journal of cancer research. 6(9):1996-2009 [PMID] 27725905.
2014
Tobacco smoke induces epithelial barrier dysfunction via receptor EphA2 signaling.
American journal of physiology. Cell physiology. 306(12):C1154-66 [DOI] 10.1152/ajpcell.00415.2012. [PMID] 24717580.
2012
Advances in malignant pleural mesothelioma therapy: targeting EphA2 a novel approach.
American journal of cancer research. 2(2):222-34 [PMID] 22432060.
2012
Fluticasone propionate and Salmeterol combination induces SOCS-3 expression in airway epithelial cells.
International immunopharmacology. 12(1):217-25 [DOI] 10.1016/j.intimp.2011.11.014. [PMID] 22155101.
2011
EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene.
Cancer gene therapy. 18(11):806-16 [DOI] 10.1038/cgt.2011.50. [PMID] 21869823.

Grants

Oct 2020 – Dec 2023
Novel biomarkers for alpha 1-antitrypsin mediated liver disease in circulating exosomes
Role: Principal Investigator
Funding: ALPHA ONE FOU

Education

Ph.D
2009 · Science and Investigation, Tehran

Contact Details

Phones:
Business:
(352) 294-5198
Emails:
Addresses:
Business Mailing:
PO Box 100225
GAINESVILLE FL 32610
Business Street:
PO BOX 100225
GAINESVILLE FL 32611